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Stephen M Hahn Selected Research

Nelfinavir (Viracept)

10/2019Clinical Outcomes of the HIV Protease Inhibitor Nelfinavir With Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non-Small Cell Lung Cancer: A Phase 1/2 Trial.
1/2019Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma.
1/2014A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme.
4/2012A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response.
8/2011Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
5/2007Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.
9/2006Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.

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Stephen M Hahn Research Topics

Disease

71Neoplasms (Cancer)
01/2020 - 02/2002
27Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2019 - 05/2002
11Hypoxia (Hypoxemia)
09/2012 - 03/2004
10Prostatic Neoplasms (Prostate Cancer)
04/2015 - 02/2002
8Sarcoma (Soft Tissue Sarcoma)
10/2020 - 03/2004
8Lung Neoplasms (Lung Cancer)
01/2018 - 05/2002
7Neoplasm Metastasis (Metastasis)
10/2020 - 03/2006
7Brain Neoplasms (Brain Tumor)
09/2015 - 03/2004
7Glioblastoma (Glioblastoma Multiforme)
04/2014 - 05/2007
6Malignant Mesothelioma
03/2017 - 03/2003
6Mesothelioma
05/2012 - 03/2003
5Carcinoma (Carcinomatosis)
06/2014 - 05/2002
4Circulating Neoplastic Cells
11/2018 - 06/2014
4Melanoma (Melanoma, Malignant)
11/2018 - 01/2015
4Head and Neck Neoplasms (Head and Neck Cancer)
05/2015 - 05/2002
3Pleural Effusion (Pleural Effusions)
03/2010 - 01/2006
3Pancreatic Neoplasms (Pancreatic Cancer)
09/2005 - 08/2004
3Necrosis
09/2004 - 04/2003
2Radiation Pneumonitis
01/2019 - 09/2010
2Body Weight (Weight, Body)
03/2010 - 01/2006
2Noninfiltrating Intraductal Carcinoma (DCIS)
02/2010 - 09/2009
2Peritoneal Neoplasms
04/2006 - 01/2005
2Ovarian Neoplasms (Ovarian Cancer)
10/2005 - 03/2004
2Capillary Leak Syndrome
07/2003 - 06/2003
1Spontaneous Fractures (Pathological Fracture)
01/2019
1Adenocarcinoma
01/2019
1Pain (Aches)
01/2019
1Mediastinal Diseases
01/2018
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2018
1Anemia
01/2018
1Hydronephrosis
01/2017
1Lymphoma (Lymphomas)
09/2016
1Chordoma
05/2016

Drug/Important Bio-Agent (IBA)

231-phenyl-3,3-dimethyltriazene (PDT)IBA
01/2020 - 01/2002
8Pharmaceutical PreparationsIBA
01/2019 - 04/2003
8Oxygen (Dioxygen)IBA
07/2011 - 03/2004
8Dihematoporphyrin Ether (Porfimer Sodium)FDA Link
01/2009 - 04/2003
7Nelfinavir (Viracept)FDA Link
10/2019 - 09/2006
7Protons (Proton)IBA
01/2017 - 05/2013
7Photosensitizing Agents (Photosensitizers)IBA
04/2006 - 03/2002
5Telomerase (Telomerase Reverse Transcriptase)IBA
01/2020 - 04/2014
5azomycinIBA
11/2010 - 12/2004
5motexafin lutetium (Lutrin)IBA
08/2008 - 01/2002
5Farnesyltranstransferase (Farnesyltransferase)IBA
09/2005 - 05/2002
4Hemoglobins (Hemoglobin)IBA
01/2018 - 05/2002
4Biomarkers (Surrogate Marker)IBA
01/2018 - 08/2013
3ErbB Receptors (EGF Receptor)IBA
01/2020 - 08/2009
3HIV Protease InhibitorsIBA
10/2019 - 09/2006
3Protease Inhibitors (Protease Inhibitor)IBA
01/2014 - 05/2007
3L 778,123IBA
11/2004 - 05/2002
2CytokinesIBA
01/2019 - 07/2003
2AntibodiesIBA
01/2017 - 06/2010
2Complement System Proteins (Complement)IBA
11/2016 - 01/2015
2AntigensIBA
05/2016 - 09/2013
2Temozolomide (Temodar)FDA LinkGeneric
01/2014 - 05/2007
2GoldIBA
12/2013 - 08/2013
2Proteins (Proteins, Gene)FDA Link
08/2011 - 09/2005
2Biological FactorsIBA
02/2010 - 09/2009
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2009 - 09/2006
2Prostate-Specific Antigen (Semenogelase)IBA
08/2008 - 02/2002
2acetamideIBA
12/2004 - 07/2004
2nitroxylIBA
10/2004 - 01/2003
2tempolIBA
10/2004 - 01/2003
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020
1Opioid Analgesics (Opioids)IBA
01/2019
1Analgesics (Analgesic Drugs)IBA
01/2019
1Morphine (MS Contin)FDA LinkGeneric
01/2019
1pembrolizumabIBA
11/2018
1IronIBA
01/2018
1insulin receptor-related receptor (IRR)IBA
01/2018
1HepcidinsIBA
01/2018
1Pemetrexed (MTA)FDA Link
03/2017
1P 536IBA
01/2017
1Immune Checkpoint InhibitorsIBA
11/2016
1Carcinoembryonic AntigenIBA
05/2016
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
05/2016
1Mucin-1 (CA 15-3 Antigen)IBA
05/2016
1CalreticulinIBA
05/2016
1CTLA-4 AntigenIBA
03/2016
1Phosphates (Orthophosphate)IBA
03/2016
1VaccinesIBA
03/2016

Therapy/Procedure

48Radiotherapy
01/2019 - 05/2002
27Photochemotherapy (Photodynamic Therapy)
01/2020 - 01/2002
21Therapeutics
01/2019 - 02/2002
13Drug Therapy (Chemotherapy)
10/2020 - 03/2006
10Proton Therapy
01/2019 - 05/2012
6Immunotherapy
01/2019 - 11/2015
6Pneumonectomy (Lung Volume Reduction)
05/2012 - 03/2003
5Chemoradiotherapy
10/2019 - 07/2011
5Combined Modality Therapy
01/2018 - 03/2003
4Re-Irradiation
01/2019 - 05/2015
3Adjuvant Radiotherapy
04/2012 - 11/2009
2Precision Medicine
12/2013 - 08/2013
2Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
05/2013 - 05/2012
2Aftercare (After-Treatment)
09/2006 - 01/2006
2Electrodes (Electrode)
12/2004 - 03/2004
1Salvage Therapy
01/2018
1Stents
01/2017
1Heavy Ion Radiotherapy
01/2017
1Particle Accelerators
07/2016